Endometrial cancer is the most common gynecologic cancer in the United States.
Most cases of endometrial cancer are diagnosed at an early stage due to the presence of noticeable symptoms, such as irregular vaginal bleeding. Although the prognosis for patients diagnosed with early-stage disease is good, the prognosis for patients with metastatic disease is poor due to the scarcity of effective treatment options. Choice of treatment for endometrial cancer depends on many factors, including stage, grade, and histology, and may involve surgery, radiation therapy, and/or systemic therapy. Clinical trials are ongoing to explore novel therapies and therapeutic combinations for the treatment of endometrial cancer.
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The incorporation of immunotherapy with chemotherapy is an exciting investigational treatment for endometrial cancer, and testing for microsatellite instability or deficient mismatch repair may allow identification of patients most likely to benefit from immunotherapy.