Platinum resistance is one of the most difficult challenges in treating recurrent ovarian cancer.
Typically characterized by disease progression within 6 months of platinum-based chemotherapy, recurrent platinum-resistant ovarian cancer is associated with poor prognosis. Current treatment goals consist of disease control, prolongation of life, improvement in quality of life, and palliation. Available treatments are limited to options such as chemotherapy ± anti-angiogenics or PARPi monotherapy. However, many new therapies and combination approaches are under investigation.
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Platinum-resistant ovarian cancer remains one of today’s most difficult clinical challenges. Currently available treatments provide only short-term responses, highlighting a significant unmet need.